The NFL by no means shies away from loading up the opening week with must-see matchups, and the Week 1 NFL schedule, which begins in two weeks, is not any totally different. From divisional battles like Chiefs vs. Broncos (+2.5) and Cowboys vs. Giants (+2.5) to Aaron Rodgers’ final trip in Steelers vs. Falcons (+3), you will have a bevy of intriguing choices to put Week 1 NFL bets on. Meanwhile, Dolphins vs. Raiders is a matchup that will not garner as a lot curiosity because the aforementioned, however it nonetheless carries intrigue for Week 1 NFL picks as the one opening recreation assured to have two new starters beneath heart. Bet NFL games at DraftKings. Claim their new user offer here:
Miami’s Malik Willis is anticipated to duel with Kirk Cousins, whereas No. 1 decide Fernando Mendoza is anticipated to start the 2026 NFL season because the backup. Vegas is a 3.5-point favourite, per the newest Week 1 NFL odds, because it’s certainly one of a dozen video games with an NFL unfold beneath 4 factors. All of the updated Week 1 NFL lines are listed below, and SportsLine’s advanced computer model has all the NFL betting advice and NFL predictions you need to make the best Week 1 NFL picks now.
The mannequin, which simulates each NFL recreation 10,000 occasions, is up properly over $7,000 for $100 gamers on betting sites on top-rated NFL picks since its inception. The mannequin enters the 2026 NFL season on a 53-37 run on top-rated picks courting again to 2024. Anybody following its picks at NFL betting sites might have seen robust returns.
Now, it has turned its consideration to the newest Week 1 NFL odds and NFL betting strains and locked in betting picks for each NFL matchup. Head here to see every pick.
Top Week 1 NFL predictions
We can inform you one of many mannequin’s strongest Week 1 NFL picks for the best betting apps is that the Jaguars (-7.5, 40.5) cowl at dwelling versus Cleveland in a Sunday 1 p.m. ET kickoff. The mannequin has the Jags prevailing versus the unfold practically 60% of the time, persevering with the success they’d final 12 months with a league-best 12-5 ATS mark within the common season. Jacksonville was much more proficient versus the road at dwelling, overlaying in 78% of video games, additionally the very best file within the NFL, whereas Cleveland was 2-6 ATS on the street, which was the second-worst mark within the NFL. SportsLine’s mannequin additionally has the Over hitting in 63% of simulations. See which other teams to pick here.
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Another certainly one of its Week 1 NFL predictions: the Eagles (-4.5, 45.5) cowl versus the Commanders on Sunday at 4:25 p.m. ET. Philadelphia has gained eight of its final 9 versus Washington in video games that Jalen Hurts has began and completed. He ought to have continued manufacturing versus Washington’s protection which ranked useless final in yards allowed final 12 months and is in transition, with as much as eight new starters and shifting from a 4-3 base to a 3-4. Add in that Jayden Daniels might use his legs much less to keep away from the accidents he suffered in 2025, and the truth that Commanders LT Laremy Tunsil (triceps) is out, and Philly is forecasted to cowl the unfold in practically 60% of simulations in an A-rated decide. See which other teams to pick here.
How to make Week 1 NFL picks
The mannequin has additionally made the decision on who wins and covers in each different recreation on the Week 1 NFL schedule and simply revealed a number of underdogs that outright win, probably supplying you with an enormous payday. You can only get every pick for every game at SportsLine.
So what Week 1 NFL picks are you able to make with confidence, and which underdogs do you have to lock in now? Check out the newest NFL odds beneath, then visit SportsLine to see which teams win and cover the spread, all from a proven computer model that has returned well over $7,000, and discover out.
Week 1 NFL betting odds, strains, dwell spreads, scores
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