A pair of American League groups will meet for the second of a three-game set on Tuesday’s MLB schedule because the Houston Astros go to the Cleveland Guardians. Houston (9-15) is final within the AL West however ended a four-game shedding streak by taking Monday’s contest 9-2. Cleveland (13-11) is atop the AL Central and was 5-1 in collection openers earlier than shedding yesterday. Ryan Weiss (0-2, 6.75 ERA) will take the mound for the Astros, whereas the Guardians will counter with Parker Messick (3-0, 1.05 ERA).
First pitch is at 6:10 p.m. ET from Progressive Field in Cleveland. The newest Guardians vs. Astros odds listing Cleveland because the -155 favourite on the cash line (danger $155 to win $100). The over/underneath for complete runs is 8.5. Before making any Astros vs. Guardians picks or MLB predictions, you’ll want to see the Guardians vs. Astros predictions and betting advice from SportsLine’s proven computer model.
Visit our DraftKings promo code assessment to see their newest affords and get began.
The SportsLine Projection Model simulates each MLB recreation 10,000 occasions. It was a worthwhile 35-29 on top-rated MLB money-line picks final season. It additionally excelled making residence run prop picks in 2025, returning practically 30 models of revenue. Anybody following its MLB betting picks at sportsbooks and on betting sites might have seen robust returns.
Now, the model has set its sights on Guardians vs. Astros and simply locked in its picks and MLB predictions. You can head to SportsLine now to see the model’s picks. Here are a number of MLB odds and betting strains for Astros vs. Guardians:
Guardians vs. Astros cash line | Guardians -155, Astros +130 |
Guardians vs. Astros over/underneath | 8.5 runs |
Guardians vs. Astros run line | Guardians -1.5 (+133) |
Guardians vs. Astros picks | See picks at SportsLine |
Guardians vs. Astros streaming | Fubo (Try for free) |
New to sports activities buying and selling? Visit our Kalshi promo code assessment to see their newest affords and get began.
Top Astros vs. Guardians predictions
After 10,000 simulations of Guardians vs. Astros, the model is going Over 8.5 mixed runs. For over/under betting, no crew has hit the Over greater than Houston this yr, with Monday’s contest being the newest occasion. The Over is 17-7 for the Astros and has hit in every of its final 4 video games. The Over additionally sports activities a 6-3 report for Cleveland over its final 9.
Houston leads the AL in OPS whereas rating useless final in ERA, so each groups typically mild up the scoreboard when the Astros are in motion. Having Weiss on the mound will not assist with the latter as he is given up 10 ER over his final 8.2 IP, however Houston can be projected to have the highest two batters by way of complete bases accrued. Both groups are forecasted to attain over 4 runs, on common, because the Over has the entire worth. Get the Astros vs. Guardians money-line pick at SportsLine.
How to make Guardians vs. Astros picks
After simulating each pitch of Astros vs. Guardians 10,000 occasions, the model additionally says one aspect of the cash line has all the worth. You can get that pick at SportsLine.
So who wins Guardians vs. Astros, and which aspect of the cash line has all the worth? Visit SportsLine now to see which side you need to jump on, all from the model that has crushed its MLB picks, and discover out.
